GABA

gamma-Aminobutyric acid, or γ-aminobutyric acid /ˈɡæmə əˈmiːnoʊbjuːˈtɪrɪk ˈæsɪd/, or GABA/ˈɡæbə/, is the chief inhibitoryneurotransmitter in the developmentally mature mammalian central nervous system. Its principal role is reducing neuronal excitability throughout the nervous system. In humans, GABA is also directly responsible for the regulation of muscle tone.[2]
gamma-Aminobutyric acid
Simplified structural formula
GABA molecule
Names
Preferred IUPAC name
4-Aminobutanoic acid
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard100.000.235
EC Number200-258-6
KEGG
MeSHgamma-Aminobutyric+Acid
PubChem CID
RTECS numberES6300000
UNII
Properties
C4H9NO2
Molar mass103.120 g/mol
Appearancewhite microcrystalline powder
Density1.11 g/mL
Melting point203.7 °C (398.7 °F; 476.8 K)
Boiling point247.9 °C (478.2 °F; 521.0 K)
130 g/100 mL
log P−3.17
Acidity (pKa)
  • 4.031 (carboxyl; H2O)
  • 10.556 (amino; H2O)[1]
Hazards
Main hazardsIrritant, Harmful
Lethal dose or concentration (LD, LC):
LD50 (median dose)
12,680 mg/
Location: Kansas City, MO 64106, USA

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